Gregg Spiridellis of JibJab is presenting at Gnomedex 2007.  JibJab has been self-funded by Gregg and his brother from the beginning (1999) and, through a lot of hard work, kept it going through the dot com crash and, as pretty much everyone knows, hit it big with the "This Land" political animated video before the 2004 election.

They're just now releasing a new beta of something called "Starring You!" which allows you to put your own head into animated videos and then send/share the results with friends.  It's very funny and it appears that they'll continue to be profitable!